This syndrome was initially described in 1900 by Klippel and Trénaunay and was originally called naevus vasculosus osteohypertrophicus. The Vascular Anomalies clinic at Le Bonheur Children’s Hospital is the only program in the region providing coordinated care for vascular anomalies (blood vessels that have developed abnormally). if (document.compatMode && document.compatMode == 'BackCompat') { See our, URL of this page: https://medlineplus.gov/genetics/condition/parkes-weber-syndrome/. Parkes-Weber Syndrome Clinical Presentation and ISSVA Diagnostic Criteria .— PWS is often misdiagnosed as KTS; however, the key clinical difference between these two disorders is the association of PWS with high-flow AVMs, as compared with the association of KTS with low-flow malformations ( 36 , 72 – 74 ). Hum Mutat.