Central nervous system (CNS) metastases rarely occur in patients with neuroblastoma, although recent reports suggest an increase in the rate. It develops from the nerve cells right in the fetus known as neuroblasts. These calvarial lesions often extend to produce epidural deposits. Metastatic CNS neuroblastoma may also occur anywhere in the CNS as a parenchymal, intraventricular, or spinal cord mass. Neuroblastoma has diverse manifestations including masquerading as primary neurologic disease. Complications of neuroblastoma may include: 1. The search for neuroblastoma lung metastases, which occur more frequently than previously reported, is clinically important because their presence portends a poor prognosis. Clinical Cases Authors. Other accompanying syndromes include: 1. Discussion. Neuroblastoma is the most common extracranial pediatric neoplasm and the third most common pediatric malignancy after leukemia and central nervous system (CNS) tumors. doi: 10.1097/MD.0000000000022630.ABSTRACTRATIONABLE: Olfactory neuroblastoma (ONB) is a rare malignant tumor of the nasal cavity, the primary local symptoms are usually inconspicuous. (a) A postcontrast computed tomography (CT) scan at the time of diagnosis (coronal view) showing skull metastasis with extradural involvement (arrow). The patient had a single supratentorial central nervous system (CNS) parenchymal metastasis from neuroblastoma and concomitant bone and bone marrow recurrence. Diagnosis. Even though congenital metastatic neuroblastoma presents a favorable prognosis, it may lead to death if not recognized and treated early on. ... Neuroblastoma metastases are very prevalent, with bone marrow (70%), bone (55%), and liver being the most affected sites [1]. Neuroblastoma occurs with slightly more frequency in males than in females. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. 1980;4 (3): 316-9. most common site of metastatic disease and important prognostic factor: Bone: Common: Permeative, Lytic, Periosteal Reaction: Metastatic involvement of the skull has been found in up to 25% of patients with neuroblastoma. Hidehiro OKURA, Kenji YATOMI, Youhei SAITO, Chinatsu KASUGA, Hisato ISHII, Kostadin KARAGIOZOV, Masakazu MIYAJIMA, Hajime … 14 Originally described in 1971, stage 4S characterizes children under 12 months of age with metastases confined to the liver, skin, and bone marrow (with less than 10% of tumoral cells). Dr. Sethi is Editor-in-Chief of Internet Journal of Radiology. (2015) Neuroblastoma: Radiological Diagnosis of a Case with Pulmonary Metastases. Neuroblastoma (NBL) is the most common extra-cranial tumour in childhood. OBJECTIVE. INRGSS uses imaging tests (usually a CT or MRI scan, and an MIBG scan), as well as exams and biopsies to help define the stage. 5A, 5B). Skull—Metastatic involvement of the skull has been found in up to 25% of patients with neuroblastoma. Neuroblastoma is the most common malignant metastasis to the skull in children [3]. Neuroblastoma metastases are very prevalent, with bone marrow (70%), bone (55%), and liver being the most affected sites [1]. We retrospectively reviewed neuroimaging examinations of 90 neuroblastoma patients whose cases were presented at neurooncology tumor board rounds over the previous 3 years at Memorial Sloan-Kettering Cancer Center (MSKCC). Casola G, Scheible W, Leopold GR (1984) Neuroblastoma metastatic to the testis: ultrasonographic screening as an aid to clinical staging. Spinal cord compression. kramerk@mskcc.org. Neuroblastoma Katherine K. Matthay Daphne Haas-Kogan Louis S. Constine Neuroblastoma (NB) is a malignancy derived from embryonic neural crest cells of the peripheral sympathetic nervous system. CT demonstration of dural metastases in neuroblastoma. Kramer K(1), Khan O(2), Haque S(3). AJR Am J Roentgenol 2010;194(5):1223–1229. Case 1: with spiculated periostitis "hair on end", spiculated periorbital bone mass, typically involving the roof or lateral wall/sphenoid wings, cranial metastasis nearly always extradural (may mimic epidural or subdural hematoma), MIBG (meta-iodo benzyl guanidine): avid uptake by neural crest tumors, TC-99-m-MDP: shows increased uptake due to the calcium metabolism of the tumor, PET: shows high sensitivity and specificity for recurrent tumors, usually associated with intraparenchymal masses.

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